Green Chemistry Articles of Interest to the Pharmaceutical Industry Marian C. Bryan*, Charlotte Dalton, Alba Díaz-Rodríguez, Jaika Doerfler, Oliver D. Engl, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Wei Li, Rachel H. Munday, Jan Pawlas, Paul F. Richardson, William J. Smith III, Alan Steven*, Balaram S. Takale, Jack A. Terrett, Daniel S. Treitler, and Mingshuo Zeng., Org. Process Res. Dev. 2023, 27, 4, 563–570. Publication Date: April 4, 2023. https://doi.org/10.1021/acs.oprd.3c00065

Green Chemistry Articles of Interest to the Pharmaceutical Industry Melissa A. Ashley, Miles H. Aukland, Marian C. Bryan*, Megan A. Cismesia, Oliver D. Engl, Pascal S. Engl, Álvaro Enriquez Garcia, Alejandro Gimenez Molina, George Karageorgis, Christopher B. Kelly, Alexandre Leclair, Wei Li, Jan Pawlas, Paul F. Richardson, Alan Steven*, Balaram S. Takale, Mingshuo Zeng, and Yongda Zhang., Org. Process Res. Dev. 2023, 27, 11, 1858-1867. Publication Date: September 13, 2023. https://doi.org/10.1021/acs.oprd.3c00258

A Chemistry in Water Reproducibility Study: Learnings from a Pre-Competitive, Multi-Company Collaboration Richard Fox, Daniel Bailey, Jennifer Obligacion, Niginia Borlinghaus, Wilfried Braje, Xiaoyong Li, Subha Mukherjee, Adeline Schoen, Timothy Towne, Stella Vukelic., ChemRxiv. 2023. Publication Date: November 17, 2023. https://doi.org/10.26434/chemrxiv-2023-mgww0

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Bryan, M.C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O.D.; Ferguson, P.; Gimenez Molina, A.; Han. Z. S.; Hasford, J.; Howell, G.P., et. al. Org. Process Res. Dev. 2022, 26(2), 251-262.
https://doi.org/10.1021/acs.oprd.2c00020

Importance of Green Chemistry and Sustainable Chemistry in the Chemical Laboratory
Colberg, J.; Hii, K. K.; Koenig, S. ACS Sustain. Chem. Eng. 2022, 10(26), 8239-8241.
https://doi.org/10.1021/acssuschemeng.2c03306

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Bryan, M.C.; Dalton, C.; Doerfler, J.; Engl, O.D.; Ferguson, P.; Gimenez Molina, A.; Harawa, V.; Hasford, J.; Howell, G.P., Kelly, C.B.; et. al. Org. Process Res. Dev. 2022, 26(9), 2550-2559.
https://doi.org/10.1021/acs.oprd.2c00274

Green and Sustainable Metrics: Charting the Course for Green-By-Design Small Molecule API Synthesis
Rose, H.B.; Kosjek, B.; Armstrong, B.M.; Robaire, S.A. Curr. Opin. Green Sustain. Chem. 2022, 5, 100324.
https://doi.org/10.1016/j.crgsc.2022.100324 

Streamlined Life Cycle Assessment of Single Use Technologies in Biopharmaceutical Manufacture
Budzinski, K.; Constable, D.; D’Aquila, D.; Smith, P.; Madabhushi, S.R.; Whiting, A.; Costelloe, T.; Collins, M. New. Biotech. 2022, 68, 28-36.
https://doi.org/10.1016/j.nbt.2022.01.002

Walter Cabri, Alessandra Tolomelli, and Lucia Ferrazzano, University of Bologna, $80,000
“New technology for continuous flow liquid-phase sustainable synthesis of therapeutic peptides”

Hans Renata of Rice University, $80,000
“Biocatalytic Synthesis of Phosphorothioate-Containing Nucleosides”

Marcel Schreier and Shannon Stahl of the University of Wisconsin Madison, $80,000
“Realizing the advantages of alternating polarity electrosynthesis at constant potential through controlled mass transport”

Andrew Teixeira and Patricia Musacchio of Worcester Polytechnic Institute, $80,000
“Overcoming light penetration challenges in photochemical reactions through a micro-LED packed bed reactor”

Jeffrey Lipshultz, Stony Brook University, $40,000
“Aminomutase-Inspired Green Radical Amination”

Marvin Parasram, New York University, $40,000
“Dihydroxylation of Propellanes via Tandem Cycloaddition/Hydrogenation of Photoexcited Nitroarenes”

Bruce Arndtsen, McGill University, $40,000
“A Versatile Approach to Carboxylic Acid Derivatives with Earth Abundant Catalysts and Visible Light”

Neil Dixon, Manchester Institute of Biotechnology, $40,000
“Sustainable Solvent Production”

Yang Hai, University of California Santa Barbara, $50,000
“Application of a PLP-dependent Mannich cyclase for biocatalytic synthesis of heterocyclic quaternary α-amino acids”

C. Oliver Kappe, University of Graz, Austria, $50,000
“Simplified PAT Strategies for Calibration-Free Real-Time Data Gathering and Utilization in Automated Flow Chemistry Platforms”

Christopher Sandford, Dartmouth College, $50,000
“Bifunctional Organocatalysts for Sustainable Peptide Bond Formation”

Nicholas Snow, Seton Hall University, $50,000
“‘Greening’ Pharmaceutical Analysis Using Gas Chromatography”

Jack Norton and Aaron Moment, Columbia University, $50,000
“Selective reduction of aromatic rings in advanced scaffolds in flow reactors with non-noble metal catalysis under mild conditions”

Masad J. Damha, McGill University, $50,000
“Oligonucleotide synthesis by resonant acoustic mixing (RAM)”

Jesús Fernández Lucas, Universidad Europea de Madrid, Spain, $25,000
“Enzymatic synthesis of C-nucleosides”

Yu Zhao, National University of Singapore, $25,000
“Electrocatalytic Functionalization of Commodity Alcohols to Produce Valuable Amines and Amides”

Duncan Browne, University College of London, $50,000
“Learning to Extrude Chemical Reactions”

Malgorzata Chwatko, University of Kentucky, $50,000
“Improvement of Peptide Yield and Solvent Reuse via Membrane Enhanced Peptides Synthesis”

Hans Renata, Scripps Research, $50,000
“Biocatalytic Synthesis of Challenging Noncanonical Amino Acids”

Jennifer Schomaker, University of Wisconsin-Madison, $50,000
“Tunable Catalytic C(sp3)-H Functionalization of Heterocyclic Scaffolds”

Qiu Wang, Duke University, $25,000
“Copper-Catalyzed Carbon-Carbon Coupling of Alcohols and Alkenes”

Han Sen Soo, Nanyang Technological University, Singapore, $25,000
“Photocatalytic Carbon-Carbon Bond Activation and Functionalization to Access Unnatural α-Amino Acids”

Mélanie Hall, University of Graz, Austria, $25,000
“Enzymatic nitration strategies for the biocatalytic synthesis of nitrogen containing molecules”

Florian Hollfelder, University of Cambridge, $25,000
“Exploring fitness landscapes of enzymes for chiral synthesis”