Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing; Benjamin I. Andrews, Firoz D. Antia, Shawn B. Brueggemeier, Louis J. Diorazio, Stefan G. Koenig, Michael E. Kopach, Heewon Lee, Martin Olbrich, and Anna L. Watson. J. Org. Chem. 2021, 86, 1, 49-61. DOI: 10.1021/acs.joc.0c02291 Green Chemistry Articles of Interest to the Pharmaceutical Industry; Charlotte Dalton, Louis J. Diorazio, Jaika Doerfler, Oliver D. Engl, Zhengxu S. Han, Gareth P. Howell, Jonathan Latham, Wei Li, Mark McLaws, Rachel H. Munday, Antonio Navarro, Michael Parmentier, Jan Pawlas, Paul Richardson, Gheorghe-Doru Roiban, Alan Steven, Jack A. Terrett, Daniel S. Treitler, and Mingshuo Zeng. J. Org. Chem. 2021, Published ASAP. 10.1021/acs.oprd.1c00067

Green Chemistry Articles of Interest to the Pharmaceutical Industry; Marie-Gabrielle Braun, Oliver Engl, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Jonathan Latham, Lucie E. Lovelle, Mark McLaws, Paul Richardson, Philipp C. Roosen, Alan Steven, Jack A. Terrett, Timothy White, Jingjun Yin. Org. Process Res. Dev. 2020, 24, 6, 897–908. DOI: 10.1021/acs.oprd.0c00154

Green Chemistry Articles of Interest to the Pharmaceutical Industry; Alba Diaz Rodriguez, Charlotte Dalton, Louis Diorazio, Jaika Doerfler, Oliver D. Engl, Matthew Hickey, Gareth Howell, Marc Hutchby, Jonathan Latham, Wei Li, Rachel Munday, Paul Richardson, Philipp C. Roosen, Alan Steven, Jack A. Terrett, Daniel S. Treitler, Timothy White, and Mingshuo Zeng. Org. Process Res. Dev. 2020, 24, 11, 2394-2406. DOI: 10.1021/acs.oprd.0c00456

A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain; Stefan G. Koenig, Cisco Bee, Alina Borovika, Christiana Briddell, Juan Colberg, Guy R. Humphrey, Michael E. Kopach, Isamir Martinez, Sudhir Nambiar, Scott V. Plummer, Seth D. Ribe, Frank Roschangar, Jeremy P. Scott, Helen F. Sneddon. ACS Sustainable Chem. Eng. 2019, 7, 16937−16951. DOI: 10.1021/acssuschemeng.9b02842 Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N-Acyl Urea Activation; Christine A. Arbour, Kayla J. Belavek, Rooha Tariq, Subha Mukherjee, Janine K. Tom, Albert Isidro-Llobet, Michael E. Kopach, Jennifer L. Stockdill. J. Org. Chem. 2019, 84(2), 1035-1041. DOI: 10.1021/acs.joc.8b02418 Green Chemistry Articles of Interest to the Pharmaceutical Industry, Issue 23; Marie-Gabrielle Braun, John Hayler, Andrew Parsons, Alba Díaz-Rodríguez, Matthew Hickey, Paul Richardson, Louis Diorazio, Lucie Lovelle, Doru Roiban, Kenneth Fraunhoffer, Mark McLaws, Alan Steven. Org. Process Res. Dev. 2019, 23, 6, 1118-1133. DOI: 10.1021/acs.oprd.9b00158 Green Chemistry Articles of Interest to the Pharmaceutical Industry, Issue 24; Marie-Gabrielle Braun,  John Hayler, Andrew Parsons, Alan Steven, Jonathan Latham, Matthew Hickey, Paul Richardson, Jack A. Terrett, Louis Diorazio, Lucie Lovelle, Doru Roiban, Timothy White, Kenneth Fraunhoffer, Mark McLaws, Philipp C. Roosen, Jingjun Yin. Org. Process Res. Dev. 2019, 23, 2287-2301. DOI: 10.1021/acs.oprd.9b00450 Introduction of a process mass intensity metric for biologics; Kristi Budzinski, Megan Blewis, Philip Dahlin, Daniel D’Aquila, Julia Esparza, Jack Gavin, Sa V. Ho, Clarice Hutchens, David Kahn, Stefan G. Koenig, Robert Kottmeier, Jeff Millard, Matt Snyder, Brad Stanard, Lixin Sun. New Biotechnology. 2019, 49, 37-42. DOI: 10.1016/j.nbt.2018.07.005. Making the move towards modernized greener separations: introduction of the analytical method greenness score (AMGS) calculator; Michael B. Hicks, William Farrell, Christine Aurigemma, Laurent Lehmann, Lauren Weisel, Kelly Nadeau, Heewon Lee, Carol Moraff, Mengling Wong, Yun Huangh, Paul Ferguson. Green Chem., 2019 ,21, 1816-1826. DOI: 10.1039/C8GC03875A Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production; Albert Isidro-Llobet, Martin N. Kenworthy, Subha Mukherjee, Michael E. Kopach, Katarzyna Wegner, Fabrice Gallou, Austin G. Smith, Frank Rrochangar. J. Org. Chem. 2019, 84(8), 4615-4628. DOI: 10.1021/acs.joc.8b03001 The PMI Predictor - a Web App Enabling Green-by-Design Chemical Synthesis; A. Borovika, J. Albrecht, J. Li, A. S. Wells, C. Briddell, B. R. Dillion, L. J. Diorazio, J. R. Gage, F. Gallou, S. G. Koenig, M. E. Kopach, D. K. Leahy, I. Martinez, M. Olbrich, J. L. Piper, F. Roschangar, E. Sherer, M. D. Eastgate. ChemRxiv, Preprint 1/16/2019

Green Chemistry Articles of Interest to the Pharmaceutical Industry; Org. Process Rev. Dev., 2018, 22, (12), 1699-1711, DOI:10.1021/acs.oprd.8b00363 Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable; Org. Process Rev. Dev., 2018, 22, (10), 1344-1359, DOI:10.1021/acs.oprd.8b00237 Green Chemistry Articles of Interest to the Pharmaceutical Industry; Org. Process Rev. Dev., 2018, 22, (612), 667-680, DOI:10.1021/acs.oprd.8b00056 Inspiring process innovation via an improved green manufacturing metric: iGAL; Green Chem., 2018, 10, 2206-2211, DOI:10.1039/C8GC00616D Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited. Marian C. Bryan, Peter J. Dunn, David Entwistle, Fabrice Gallou, Stefan G. Koenig, John D. Hayler, Matthew R. Hickey, Shaun Hughes, Michael E. Kopach, Gerard Moine, Paul Richardson, Frank Roachangar, Alan Steven, Frans J. Weiberth. Green. Chem. 2018, 20, 5082-5103. DOI: 10.1039/C8GC01276H

Sustainable Practices in Medicinal Chemistry Part 2: Green by Design J. Med. Chem. 2017, 60, 5955-5968. DOI: 10.1021/acs.jmedchem.6b01837 Green Chemistry Articles of Interest to the Pharmaceutical Industry Org. Process Res. Dev. 2017, 21 (10), 1464-1477. DOI: 10.1021/acs.oprd.7b00292 Green Chemistry Articles of Interest to the Pharmaceutical Industry Marian C. Bryan, Louis Diorazio, Zhongbo Fei, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Shaun Hughes, Luke Humphreys, Paul Richardson, Markus Schober, Alan Steven, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2017, 21 (2), 153–164. DOI: 10.1021/acs.oprd.7b00014 A Deeper Shade of Green: Inspiring Sustainable Drug Manufacturing Green Chem., 2017, 19, 281-285. DOI:10.1039/C6GC02901A

Towards a More Holistic Framework for Solvent Selection Louis J. Diorazio, David R. J. Hose, Neil K. Adlington. Org. Process Res. Dev. 2016, 20 (4), 760–773. DOI: 10.1021/acs.oprd.6b00015 Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Marian C. Bryan, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Luke Humphreys, Paul Richardson, Gheorghe-Doru Roiban, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2016, 20 (4), 707–717. DOI:10.1021/acs.oprd.6b00042 Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Marian C. Bryan, Andrew Cosbie, Alba Díaz-Rodríguez, Louis Diorazio, Zhongbo Fei, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Luke Humphreys, Paul Richardson, Scott Roberts, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2016, 20 (7), 1118–1132. DOI: 10.1021/acs.oprd.6b00174

2015

• Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Andrew Cosbie, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, Luke Humphreys, Bernard Kaptein, Lynette Oh, Paul Richardson, Scott Roberts, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2015, 19 (12), 1924–1935, DOI: 10.1021/acs.oprd.5b00344
• Special Report: Toward Sustainable Engineering Practices in Biologics Manufacturing Kristen Brown, Kristi Budzinski, Sa Ho, Jeff Millard, Jeffrey Johnson, Phillip Dahlin, Barbara Owen, Robert Kottmeier. BioProcess International [Online]; 2015.

2014

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2007

Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, Luke Humphreys, Bernard Kaptein, Suju Mathew, Paul Richardson, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2014, 18 (12), 1602-1613. DOI: 10.1021/op500345y Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, David Hughes, Luke Humphreys, Bernard Kaptein, Suju Mathew, Lynnette Oh, Paul Richardson, Timothy White, Stijn Wuyts. Org. Process Res. Dev. 2014, 18 (7), 863-874. DOI: 10.1021/op500167y Sustainable Chromatography (an oxymoron?) Emily A. Peterson, Barry Dillon, Izzat T. Raheem, Paul Richardson, Daniel Richter, Rachel Schmidt, and Helen F. Sneddon. Green Chem. July 14, 2014 (web), DOI: 10.1039/C4GC00615A

2013 Year in Review Highlights recent accomplishments of the ACS GCI Pharmaceutical Roundtable. 3rd Annual ACS GCI Roundtable Poster Reception Abstracts June 19, 2013, North Bethesda, MD, USA. Expanding the Boundaries: Developing a Streamlined Tool for Eco-Footprinting of Pharmaceuticals Concepción Jiménez-González, Caleb Ollech, William Pyrz, David Hughes, Quirinus B. Broxterman, and Neil Bhathela. Org. Process Res. Dev. 2013, 17 (2), 239–246. Publication Date (Web): January 3, 2013 (Article), DOI: 10.1021/op3003079 Filling Gaps During Carbon Footprint Studies to Design Green Pharmaceuticals Go with the Flow Juan Colberg, Stefan Koenig, David Leahy, and Peter Poechlauer. Innovations in Pharmaceutical Technology, 2013, Issue 46, 52-55. Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, David Hughes, Luke Humphreys, Bernard Kaptein, Suju Mathew, Lynnette Oh, Paul Richardson, Timothy White, Stijn Wuyts. Org. Process Res. Dev. 2013, 17 (11), 1394–1405. DOI: 10.1021/op400263a Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor, Apurba Bhattacharya, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, William Hinkley, David Hughes, Luke Humphreys, Bernard Kaptein, Suju Mathew, Thomas Rammeloo, Paul Richardson, Timothy White. Org. Process Res. Dev. 2013, 17 (4), 615–626. DOI: 10.1021/op4000434 Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes Peter Poechlauer, Juan Colberg, Elizabeth Fisher, Michale Jansen, Martin D. Johnson, Stefan G. Koenig, Michael Lawler, Thomas Laporte, Julie Manley, Benjamin Martin, and Ann O’Kearney-McMullan. Org. Process Res. Dev. 2013, 17 (12), 1472-1478. DOI: 10.1021/op400245s Seven Important Elements for an Effective Green Chemistry Program: An IQ Consortium Perspective David K. Leah; John L. Tucker; Ingrid Mergelsberg; Peter J. Dunn; Michael E. Kopach; and Vikram C. Purohit. Org. Process Res. Dev. 2013, 17, 1099−1109. DOI: /10.1021/op400192h Sustainable Practices in Medicinal Chemistry: Current State and Future Directions Bryan, Marian C.; Dillon, Barry; Hamann, Lawrence G.; Hughes, Gregory J.; Kopach, Michael E.; Peterson, Emily A.; Pourashraf, Meharnez; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen. J. Med. Chem. [online early access] DOI: 10.1021/jm400250p. Published Online: April 15, 2013.

Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective Peter Poechlauer, Julie Manley, Rinus Broxterman, Björn Gregertsen, and Mats Ridemark. Org. Process Res. Dev. 2012, 16 (10), 1586–1590. Publication Date (Web): September 18, 2012 (Concept Article), DOI: 10.1021/op300159y Green Chemistry Articles of Interest to the Pharmaceutical Industry L. Amarnath, Ian Andrews, Rakeshwar Bandichhor, Apurba Bhattacharya, Peter Dunn, John Hayler, William Hinkley, Nicole Holub, David Hughes, Luke Humphreys, Bernard Kaptein, Hare Krishnen, Kurt Lorenz, SujuMathew, G. Nagaraju, Thomas Rammeloo, Paul Richardson, Lijun Wang, Andrew Wells, Timothy White. Org. Process Res. Dev. 2012, 16 (4), 535–544. DOI: 10.1021/op300068d Green Chemistry Articles of Interest to the Pharmaceutical Industry Rakeshwar Bandichhor , Apurba Bhattacharya, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, David Hughes, Luke Humphreys, Bernd Janocha, Bernard Kaptein, Suju Mathew, Thomas Rammeloo, Paul Richardson, Timothy White. Org. Process Res. Dev. 2012, 16 (12), 1887–1896. DOI: 10.1021/op300251d Greener Journals Stephen K. Ritter. Chemical & Engineering News. 90(5), January 30, 2012 Green Chemistry is Good Process Chemistry Trevor Laird (Editor). Org. Process Res. Dev. 2012, 16 (1), 1–2. DOI: 10.1021/op200366y Pharma Strives for Green Goals Ann M. Thayer. Chemical & Engineering News. 90(22), May 28, 2012 Solvent Choices and Sustainable Chemistry Guido M. Kemeling. ChemSusChem. December 3, 2012, 5(12), 291-2292. DOI:10.1002/cssc.201200873 Use of the Electronic Laboratory Notebook to Facilitate Green Chemistry Within the Pharmaceutical Industry Michael E. Kopach, Emily A. Reiff. Future Medicinal Chemistry. July 2012, 4(11), 1395-1398. DOI: 10.4155/fmc.12.78

2011 Year in Review Highlights recent accomplishments of the ACS GCI Pharmaceutical Roundtable. Green Chemistry Articles of Interest to the Pharmaceutical Industry Ian Andrews, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy Donald White. Org. Process Res. Dev. 2011, 15 (1), 22–30. DOI: 10.1021/op1003105 Green Chemistry Articles of Interest to the Pharmaceutical Industry Ian Andrews, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy Donald White. Org. Process Res. Dev. 2011, 15 (4), 748–756. DOI: 10.1021/op200128q Green Chemistry: Pharmaceutical Roundtable Shares Assessment Tool With Suppliers Ann M. Thayer with reporting by Rick Mullin. Chemical & Engineering News, 89(9), February 28, 2011 Green Chemistry Reporting Requirements for Electronic Laboratory Notebook Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers Concepción Jiménez-González, Peter Poechlauer, Quirinus B. Broxterman, Bing-Shiou Yang, David am Ende, James Baird, Carl Bertsch, Robert E. Hannah, Phil Dell’Orco, Henk Noorman, Sandy Yee, Raf Reintjens, Andrew Wells, Viviane Massonneau, Julie Manley. Org. Process Res. Dev. 2011, 15 (4), 900–911. DOI: 10.1021/op100327d Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry to Drive More Sustainable Processes Concepción Jiménez-González, Celia S. Ponder, Quirinus B. Broxterman, and Julie B. Manley. Org. Process Res. Dev. 2011, 15 (4), 912–917. DOI: 10.1021/op200097d

Green Chemistry Articles of Interest to the Pharmaceutical Industry Ian Andrews, Jian Cui, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy Donald White. Org. Process Res. Dev. 2010, 14 (4), 770–780. DOI: 0.1021/op100116s Green Chemistry Articles of Interest to the Pharmaceutical Industry Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy White, Fuyao Zhang. Org. Process Res. Dev. 2010,14 (1), 19–29. DOI: 10.1021/op900295s

Green Chemistry Articles of Interest to the Pharmaceutical Industry Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Stanley Kolis, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy White, Chaoyu Xie, Fuyao Zhang. Org. Process Res. Dev. 2009, 13 (3), 397–408. DOI: 10.1021/op900082k

Collaboration to Deliver a Solvent Selection Guide to the Industry Green Chemistry Articles of Interest to the Pharmaceutical Industry Stephen Challenger, Leo Dudin, Jimmy DaSilva, Peter Dunn, Tom Govaerts, John Hayler, Bill Hinkley, Yannis Houpis, Thomas Hunter, Lisa Jellet, John L. LeazerJr., Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Ravinder Sudini, Zonghui Wan, Chris Welch, Andrew Wells, Jennifer Vance, Chaoyu Xie, Fuyao Zhang. Org. Process Res. Dev. 2008, 12 (5), 807–816. DOI: 10.1021/op800175p

Key Green Chemistry Research Areas: A Perspective from Pharmaceutical Manufacturers David J. C. Constable, Peter J.Dunn, John D. Hayler, Guy R. Humphrey, Johnnie L Jr. Leazer, Russell J. Linderman, Kurt Lorenz, Julie Manley, Bruce A. Pearlman, Andrew Wells, Aleksey Zaksh, Tony Y. Zhangf. Green Chem. 2007, 9, 411-420. DOI: 10.1039/B703488C Key Green Chemistry Research Areas: A Perspective from Pharmaceutical Manufacturers Lessons Learned Through Measuring Green Chemistry Performance