2015

• Green Chemistry Articles of Interest to the Pharmaceutical Industry
  Rakeshwar Bandichhor, Apurba Bhattacharya, Andrew Cosbie, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Bill Hinkley, Luke Humphreys, Bernard Kaptein, Lynette Oh, Paul Richardson, Scott Roberts, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2015, 19 (12), 1924–1935, DOI: 10.1021/acs.oprd.5b00344
• Special Report: Toward Sustainable Engineering Practices in Biologics Manufacturing
  Kristen Brown, Kristi Budzinski, Sa Ho, Jeff Millard, Jeffrey Johnson, Phillip Dahlin, Barbara Owen, Robert Kottmeier. BioProcess International [Online]; 2015.

2014

2013

2012

2011

2010

2009

2008

2007

Towards a More Holistic Framework for Solvent Selection
Louis J. Diorazio, David R. J. Hose, Neil K. Adlington. Org. Process Res. Dev. 2016, 20 (4), 760–773. DOI: 10.1021/acs.oprd.6b00015

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Rakeshwar Bandichhor, Apurba Bhattacharya, Marian C. Bryan, Louis Diorazio, Peter Dunn, Kenneth Fraunhoffer, Fabrice Gallou, John Hayler, Matthew Hickey, Luke Humphreys, Paul Richardson, Gheorghe-Doru Roiban, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2016, 20 (4), 707–717. DOI:10.1021/acs.oprd.6b00042

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Rakeshwar Bandichhor, Apurba Bhattacharya, Marian C. Bryan, Andrew Cosbie, Alba Díaz-Rodríguez, Louis Diorazio, Zhongbo Fei, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Luke Humphreys, Paul Richardson, Scott Roberts, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2016, 20 (7), 1118–1132. DOI: 10.1021/acs.oprd.6b00174

Sustainable Practices in Medicinal Chemistry Part 2: Green by Design
J. Med. Chem. 2017, 60, 5955-5968. DOI: 10.1021/acs.jmedchem.6b01837

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Org. Process Res. Dev. 2017, 21 (10), 1464-1477. DOI: 10.1021/acs.oprd.7b00292

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Marian C. Bryan, Louis Diorazio, Zhongbo Fei, Kenneth Fraunhoffer, John Hayler, Matthew Hickey, Shaun Hughes, Luke Humphreys, Paul Richardson, Markus Schober, Alan Steven, Timothy White, Stijn Wuyts, Jingjun Yin. Org. Process Res. Dev. 2017, 21 (2), 153–164. DOI: 10.1021/acs.oprd.7b00014

A Deeper Shade of Green: Inspiring Sustainable Drug Manufacturing
Green Chem., 2017, 19, 281-285. DOI:10.1039/C6GC02901A

The Process Mass Intensity (PMI) Prediction Calculator was created by the ACS GCI Pharmaceutical Roundtable member companies, with leadership from Bristol-Myers Squibb, to predict a range of probable process efficiencies of proposed synthetic routes at various phases of drug development. The tool uses historical PMI data from multiple pharmaceutical companies and predictive analytics (Monte Carlo simulations) to estimate the probable PMI ranges. The tool can be used to predict PMI prior to any laboratory evaluation of the route; i.e., as an in-silico modeling effort, or at any other stage of a molecule’s development to assess and compare potential route changes.

PMI Prediction Calculator »

Team Lead

Alina Borovika, Bristol-Myers Squibb

Goal

Develop online application for PMI Prediction Calculator

Projects

PMI Prediction Calculator Development

The team has developed the tool which is powered by a database of about 2,000 data points collected by the Roundtable. Annual data collection to fil in underpopulated reaction subtypes

Paper

Collaboration with Prof. Waller on CASP/PMI

A. John Blacker, Ph.D., University of Leeds, $50,000
“Process Development of Continuous Flow Oxidative Biotransformations”

Graham Dobereiner, Ph.D., Temple University, $50,000
“Tandem catalytic process in flow: synthesis of amides via mild photochemical carbonylation using CO₂ as a carbonyl source”

Amanda C. Evans, Ph.D., California State University, $50,000
“Enz-Flow/Continuous Bioprocessing: Towards a green continuous flow synthesis of levomilnacipran”