ACS GCI Pharmaceutical Roundtable—Catalyzing green chemistry & engineering in the global pharmaceutical industry.

MedChem Tips and Tricks

RT member companies invest heavily in the discovery of new active pharmaceutical ingredients. Key to the success of these efforts are synthetic organic chemists who rapidly develop large libraries of synthetic analogues that are screened for potential activity against a particular disease target. There is an emphasis on the rapid identification of synthetic routes that lead to the isolation of sufficient active ingredient to perform early discovery studies. This emphasis on speed usually results in highly inefficient reaction schemes, isolations and work-ups. The Medicinal Chemistry sub-Team is organized for best practice sharing and have identified a variety of useful practices to green medicinal chemistry.

View MedChem Tips and Tricks

Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
Bryan, Marian C.; Dillon, Barry; Hamann, Lawrence G.; Hughes, Gregory J.; Kopach, Michael E.; Peterson, Emily A.; Pourashraf, Meharnez; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen. J. Med. Chem. J. Med. Chem., 2013, 56 (15), pp 6007–6021.

Sustainable Practices in Medicinal Chemistry Part 2: Green by Design
Aliagas, Ignacio; Berger, Raphaëlle; Goldberg, Kristin; Nishimura, Rachel T.; Reilly, John; Richardson, Paul; Richter, Daniel; Sherer, Edward C.; Sparling, Brian A.; Bryan, Marian C. J. Med. Chem. 2017, 60 (14), pp 5955–5968.

Team Lead

Brian Sparling, Amgen


Making green impacts in medicinal chemistry and externally.

Current Projects

Research Grants

2019 RFP for precious-metal free cross-coupling methodology for med. chem.

2018 Photochem grant with Prof. Stephenson is completed. Scott Plummer, Novartis, is the Roundtable lead. “Microfluidic reactor and late-stage functionalization of diverse scaffolds”

Project Update [link]


Academic Outreach

The Team has been holding outreach workshops and seminars at universities including UCSD, UMass Boston, MIT and Stanford in 2018.