MedChem Tips and Tricks
RT member companies invest heavily in the discovery of new active pharmaceutical ingredients. Key to the success of these efforts are synthetic organic chemists who rapidly develop large libraries of synthetic analogues that are screened for potential activity against a particular disease target. There is an emphasis on the rapid identification of synthetic routes that lead to the isolation of sufficient active ingredient to perform early discovery studies. This emphasis on speed usually results in highly inefficient reaction schemes, isolations and work-ups. The Medicinal Chemistry sub-Team is organized for best practice sharing and have identified a variety of useful practices to green medicinal chemistry.
Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
Bryan, Marian C.; Dillon, Barry; Hamann, Lawrence G.; Hughes, Gregory J.; Kopach, Michael E.; Peterson, Emily A.; Pourashraf, Meharnez; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen. J. Med. Chem. J. Med. Chem., 2013, 56 (15), pp 6007–6021.
Sustainable Practices in Medicinal Chemistry Part 2: Green by Design
Aliagas, Ignacio; Berger, Raphaëlle; Goldberg, Kristin; Nishimura, Rachel T.; Reilly, John; Richardson, Paul; Richter, Daniel; Sherer, Edward C.; Sparling, Brian A.; Bryan, Marian C. J. Med. Chem. 2017, 60 (14), pp 5955–5968.
Team Lead
Brian Sparling, Amgen
Goal
Making green impacts in medicinal chemistry and externally.
Current Projects
Research Grants
2019 RFP for precious-metal free cross-coupling methodology for med. chem.
2018 Photochem grant with Prof. Stephenson is completed. Scott Plummer, Novartis, is the Roundtable lead. “Microfluidic reactor and late-stage functionalization of diverse scaffolds”
Project Update [link]
Reports[link]
Academic Outreach
The Team has been holding outreach workshops and seminars at universities including UCSD, UMass Boston, MIT and Stanford in 2018.
